Abstract #3977

Magneto-Caloric Materials as Symmetric Reverse-Contrast Switchable MRI Labels

Mladen Barbic¹, Hatem ElBidweihy², Stephen Dodd³, H Douglas Morris⁴, and Alan P Koretsky³

¹Applied Physics and Instrumentation Group, HHMI-Janelia Reseach Campus, Ashburn, VA, United States, ²Electrical and Computer Engineering Department, United States Naval Academy, Annapolis, MD, United States, ³Laboratory of Functional and Molecular Imaging, NIH/NINDS, Bethesda, MD, United States, ⁴NIH Mouse Imaging Facility, NIH/NINDS, Bethesda, MD, United States

We describe the use of magneto-caloric materials as symmetric reverse-contrast switchable MRI labels at physiological temperatures. We present physical and temperature tunable MRI measurements on two different magneto-caloric materials, Iron-Rhodium (Fe-Rh) and Lanthanum-Iron-Silicon (La-Fe-Si) that both have sharp first-order magnetic phase transitions at the same bias DC magnetic field of 1 Tesla and physiological temperature of 37°C (310K), but with simultaneously positive and negative slope of magnetization vs. temperature, respectively, and therefore reverse image contrast in MRI. Thus, we show that different magneto-caloric materials provide an opportunity for the development of versatile multi-functional high differential contrast ratio switchable MRI labels.

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