As development of quantitative magnetization transfer (qMT) has progressed, different sequences have been developed and independently optimised. Here, we present a comparison of the three main qMT acquisition sequences: spoiled gradient echo (SPGR), selective inversion recovery with fast spin echo (SIR-FSE) and balanced steady-state free precession (bSSFP). A novel comparison is accomplished by optimising each protocol using Cramér-Rao lower bounds (CRLB) theory. Our results indicate that SPGR qMT may introduce additional uncertainty due to the low sensitivity surrounding T2f, while bSSFP may provide a robust alternative for efficient 3D acquisitions.
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