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Abstract #3980

Quantitative Magnetization Transfer: A Comparison of State-of-the-Art Acquisitions

Fritz M. Bayer1, Peter Jezzard1, and Alex K. Smith1

1Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford, United Kingdom

As development of quantitative magnetization transfer (qMT) has progressed, different sequences have been developed and independently optimised. Here, we present a comparison of the three main qMT acquisition sequences: spoiled gradient echo (SPGR), selective inversion recovery with fast spin echo (SIR-FSE) and balanced steady-state free precession (bSSFP). A novel comparison is accomplished by optimising each protocol using Cramér-Rao lower bounds (CRLB) theory. Our results indicate that SPGR qMT may introduce additional uncertainty due to the low sensitivity surrounding T2f, while bSSFP may provide a robust alternative for efficient 3D acquisitions.

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