Abstract #3988

Towards glycoCEST in the liver at 7T with a multi-transmit system

Aline Xavier¹, Vitaliy Khlebnikov², Jeanine Prompers ², Marcelo Andia¹, and Catalina Arteaga de Castro²

¹Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, ²Imaging Division, University Medical Centre Utrecht, Utrecht, Netherlands

The purpose of this work was to optimize and evaluate different parameters of the CEST acquisition protocol at 7 Tesla to be able to detect the glycoCEST signal in the human liver. The so far optimized parameters were determined as 65 frequency offsets, 60 saturation pulses of 25 ms duration and an effective B₁ of 1.5uT. As conclusion, we have demonstrated that in-vivo liver glycoCEST can be detected in the human liver by using a CEST acquisition at 7T. The parameters can be further optimized to obtain a stronger glycoCEST effect.

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