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Abstract #3987

A custom-designed 1H saddle coil for CEST imaging at 14.1 Tesla

Claudia Zanella1, Elise Vinckenbosch2, Jérémie D. Clément1, Masoumeh Dehghani1,3, Bernard Lanz1, and Rolf Gruetter1,4,5

1Laboratory for functional and metabolic imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 2School of Health Sciences, University of Applied Sciences and Arts of Western Switzerland (HES-SO), Geneva, Switzerland, 3Department of Psychiatry, McGill University, Montreal, QC, Canada, 4Department of Radiology, Université de Lausanne (UNIL), Lausanne, Switzerland, 5Department of Radiology, Geneva University Hospital (UNIGE), Geneva, Switzerland

We propose an alternative RF method for small animal CEST imaging at ultra-high magnetic field by using a 1H saddle coil instead of a quadrature birdcage coil. The coils create similar homogeneous B1 maps with an 2.2x increase of SNR for the saddle coil. Both coils show a similar degree of precision when tested for in vitro glycoCEST imaging. In rodent skeletal muscle the saddle coil offers a good performance with respect to the sensitivity for glycoCEST imaging.

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