Abstract #3987

A custom-designed 1H saddle coil for CEST imaging at 14.1 Tesla

Claudia Zanella¹, Elise Vinckenbosch², Jérémie D. Clément¹, Masoumeh Dehghani^1,3, Bernard Lanz¹, and Rolf Gruetter^1,4,5

¹Laboratory for functional and metabolic imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²School of Health Sciences, University of Applied Sciences and Arts of Western Switzerland (HES-SO), Geneva, Switzerland, ³Department of Psychiatry, McGill University, Montreal, QC, Canada, ⁴Department of Radiology, Université de Lausanne (UNIL), Lausanne, Switzerland, ⁵Department of Radiology, Geneva University Hospital (UNIGE), Geneva, Switzerland

We propose an alternative RF method for small animal CEST imaging at ultra-high magnetic field by using a ¹H saddle coil instead of a quadrature birdcage coil. The coils create similar homogeneous B₁ maps with an 2.2x increase of SNR for the saddle coil. Both coils show a similar degree of precision when tested for in vitro glycoCEST imaging. In rodent skeletal muscle the saddle coil offers a good performance with respect to the sensitivity for glycoCEST imaging.

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