Ratiometric chemical exchange saturation transfer MRI (acidoCEST) using two distinct exchangeable protons in iodinated agents has been widely developed for in vitro and in vivo pH mapping. The accuracy of acidoCEST and pH detection range greatly relies on the applied B1 saturation pulse and chemical properties of labile protons. In this study we try to make full use of different chemical property of two labile protons. Through finely adjusting their ratio, the accuracy and pH detection range under a single low-power B1 saturation has shown to be improved
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