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Abstract #3995

Development of whole-brain 3D snapshot CEST MRI at 3T

Sebastian Mueller1, Anagha Deshmane1, Kai Herz1, Klaus Scheffler1,2, and Moritz Zaiss1

1High-field Magnetic Resonance Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Department of Biomedical Magnetic Resonance, Eberhard-Karls University Tuebingen, Tuebingen, Germany

In its application Chemical exchange saturation transfer (CEST) suffers from the drawback of long acquisition times. To approach this issue we demonstrate the feasibility of a 3D gradient echo based CEST sequence for 3T that provides whole brain (WB) coverage without additional measurement time. In addition, the suggested post processing helps to improve the determination of the CEST effects from the WB data. CEST contrasts derived from the presented method are of equal quality as those of commonly used methods.

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