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Abstract #3998

Measuring the pH of human blood using CEST

Andrew John Carradus1, Olivier Mougin1, Hans Hoogduin2, and Penny Gowland1

1University of Nottingham, Nottingham, United Kingdom, 2University Medical Center Utrecht, Utrecht, Netherlands

Iopamidol has been previously used as a CEST based contrast agent to measure pH in mouse kidneys. Here we aim to move this work towards clinical translation by calibrating the pH of ex vivo human blood to the ratiometric values calculated from the two Iopamidol CEST peaks. This is performed in the physiological range for human blood, between pH 6.8 and 8.4.

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