Meeting Banner
Abstract #3997

Pulsed Saturation Transfer in Glioblastoma at 1.5T

Rachel W. Chan1, Sten Myrehaug2,3, Greg J. Stanisz1,4,5, Arjun Sahgal1,2,3, and Angus Z. Lau1,4

1Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 2Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada, 4Medical Biophysics, University of Toronto, Toronto, ON, Canada, 5Department of Neurosurgery and Pediatric Neurosurgery, Medical University, Lublin, Poland

The purpose of this study was to quantify the effects of saturation transfer (CEST and MT) measurements in glioblastoma (GBM) patients at 1.5T. Data from GBM patients (n=10), treated with intensity modulated radiation therapy with a dose of 2 Gy per session with concurrent temozolomide, were analyzed before and after 10 treatment fractions. MT data were fitted to the Bloch-McConnell (BM) equations using a two-pool model with extended phase graphs (EPG) incorporated into the model. Results showed differences between normal and tumor regions and demonstrated promise for the application of CEST at 1.5T.

This abstract and the presentation materials are available to members only; a login is required.

Join Here