Image-guided cell therapy plays an important role in monitoring and adjusting the treatment regimen. We have demonstrated that cell viability could be monitored by CEST pH-nanosensors in alginate hydrogel microbeads. Here, we investigated the use of microfluidics to generate liposome containing microbeads and examined their CEST properties after loading with the iodine CT contrast agents Iohexol and Iopamiro. We have successfully demonstrated that the microbead size has greatly reduced from 300-400 μm to 20 μm. Moreover, iodine agents loaded liposomal microbeads generated 4% CEST contrast at 4.2 ppm at 3T. These findings demonstrate a robust platform for the fabrication of liposome containing microbeads under CEST MR guidance.
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