Recently, the extended phase graph with exchange (EPG-X) formalism has been introduced for modelling magnetization transfer (MT) effects during arbitrary pulse sequences. Here, we present a further extension to include a dipolar order component of the macromolecular (i.e. semisolid) pool, as has been proposed to understand the “inhomogeneous” MT (ihMT) contrast mechanism observed in ordered structures such as myelin and muscle. Preliminary results demonstrate the flexibility of the developed simulation tool for ihMT contrast optimisation and the investigation of steady-state sequence dynamics.
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