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Abstract #4012

Robust Chemical Exchange Spin-lock performed using adiabatic pulse with Toggling Inversion Preparation at 3.0T

Baiyan Jiang1, Tao Jin2, Jian Hou1, and Weitian Chen1

1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 2Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States

The measurement of R1rho (1/T1rho) spectrum and its asymmetry have several advantages over Chemical Exchange Saturation Transfer (CEST) to probe chemical exchange effect. However, these approaches suffer from B1 Radiofrequency (RF) and B0 field inhomogeneities. In this work, we proposed a new approach to perform robust R1rho asymmetry measurement using adiabatic spin-lock RF pulse and demonstrated its potential to probe metabolites.

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