Abstract #4012

Robust Chemical Exchange Spin-lock performed using adiabatic pulse with Toggling Inversion Preparation at 3.0T

Baiyan Jiang¹, Tao Jin², Jian Hou¹, and Weitian Chen¹

¹Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, ²Department of Radiology, University of Pittsburgh, Pittsburgh, PA, United States

The measurement of R1rho (1/T1rho) spectrum and its asymmetry have several advantages over Chemical Exchange Saturation Transfer (CEST) to probe chemical exchange effect. However, these approaches suffer from B1 Radiofrequency (RF) and B0 field inhomogeneities. In this work, we proposed a new approach to perform robust R1rho asymmetry measurement using adiabatic spin-lock RF pulse and demonstrated its potential to probe metabolites.

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