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Abstract #4013

Relaxation-compensated APT and rNOE CEST-MRI of human brain tumors at 3 T

Steffen Goerke1, Yannick Soehngen1, Anagha Deshmane2, Moritz Zaiss2, Johannes Breitling1, Philip S Boyd1, Kai Herz2, Ferdinand Zimmermann1, Karel D Klika3, Mark E Ladd1, and Peter Bachert1

1Divsion of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Department of High-field Magnetic Resonance, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, 3Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, the established acquisition protocol for relaxation-compensated APT and rNOE CEST-MRI at 7 T has been successfully transferred to a clinically relevant magnetic field strength of 3 T. This opens up the door to clinical trials with a large number of participants, thus enabling a comprehensive assessment of the clinical relevance of relaxation-compensation in CEST-MRI. The presented CEST sequence is currently part of the clinical routine acquisition protocol for brain tumor patients at our institute.

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