Abstract #4013

Relaxation-compensated APT and rNOE CEST-MRI of human brain tumors at 3 T

Steffen Goerke¹, Yannick Soehngen¹, Anagha Deshmane², Moritz Zaiss², Johannes Breitling¹, Philip S Boyd¹, Kai Herz², Ferdinand Zimmermann¹, Karel D Klika³, Mark E Ladd¹, and Peter Bachert¹

¹Divsion of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Department of High-field Magnetic Resonance, Max-Planck-Institute for Biological Cybernetics, Tübingen, Germany, ³Molecular Structure Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

In this study, the established acquisition protocol for relaxation-compensated APT and rNOE CEST-MRI at 7 T has been successfully transferred to a clinically relevant magnetic field strength of 3 T. This opens up the door to clinical trials with a large number of participants, thus enabling a comprehensive assessment of the clinical relevance of relaxation-compensation in CEST-MRI. The presented CEST sequence is currently part of the clinical routine acquisition protocol for brain tumor patients at our institute.

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