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Abstract #4017

A Potentially New Class of Redox-Sensitive CEST Agents: Preliminary Thiol-CEST Studies with Glutathione and Cysteine

Johnny Chen1, Nirbhay N. Yadav2,3, Abhishek Gupta1, Tim Stait-Gardner1, William S. Price1, and Gang Zheng1

1School of Science and Health, Western Sydney University, Sydney, Australia, 2Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

In this study, we show that thiol-water proton exchange can generate MRI contrast by performing proton chemical exchange saturation transfer (1H-CEST) experiments on glutathione (GSH) and cysteine (Cys). The thiol proton exchange was quantified at various pHs, with Cys thiol exhibiting faster and more base-catalyzed exchange than GSH. However, both GSH and Cys thiol exchange were too fast to generate contrast at physiological pH. Potential applications of thiol compounds as redox-sensitive CEST agents are suggested.

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