Abstract #4018

Characterization of B1 calibration curves with respect to durations for myo-Inositol CEST ( MICEST) in the healthy human brain at 7.0T

Deepa Thakuri¹, Ravi Prakash Reddy Nanga¹, Abigail T. J. Cember¹, Dushyant Kumar¹, Neil E. Wilson¹, Hari Hariharan¹, and Ravinder Reddy¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States

myo-Inositol (MI) is one of the important brain metabolites. In the recent years, MICEST technique has emerged as a neuroimaging biomarker and its application was shown in an Alzhemer’s mouse model. In this study, we tried to explore and evaluate the behavior of MICEST at different saturation parameters in healthy human volunteers at 7.0T with an aim to understand and set optimal saturation parameters for the human studies.

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