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Abstract #4018

Characterization of B1 calibration curves with respect to durations for myo-Inositol CEST ( MICEST) in the healthy human brain at 7.0T

Deepa Thakuri1, Ravi Prakash Reddy Nanga1, Abigail T. J. Cember1, Dushyant Kumar1, Neil E. Wilson1, Hari Hariharan1, and Ravinder Reddy1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

myo-Inositol (MI) is one of the important brain metabolites. In the recent years, MICEST technique has emerged as a neuroimaging biomarker and its application was shown in an Alzhemer’s mouse model. In this study, we tried to explore and evaluate the behavior of MICEST at different saturation parameters in healthy human volunteers at 7.0T with an aim to understand and set optimal saturation parameters for the human studies.

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