Compared to conventional single-slice or small volume measurements, whole-brain CEST acquisitions present new challenges, in particular at ultra high-field (UHF). In a first step to account for the broader B1 variation, we analyzed the distribution of reference voltages in the brain of nine subjects. Based on these results, we repeated a whole-brain CEST experiment with seven different reference voltages to optimize the correction for B1 inhomogeneities in the CEST contrast maps. Additionally, we extended the saturation-offset list to compensate for the higher variation of the static magnetic field for whole-brain experiments compared to examinations with smaller FOVs.
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