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Abstract #4019

Optimized B1/B0 correction for whole-brain CEST imaging using 3D-EPI at 7T

Suzan Akbey1, Philipp Ehses1, Rüdiger Stirnberg1, Moritz Zaiss2, and Tony Stöcker1,3

1German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, 2Max-Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Department of Physics and Astronomy, University of Bonn, Bonn, Germany

Compared to conventional single-slice or small volume measurements, whole-brain CEST acquisitions present new challenges, in particular at ultra high-field (UHF). In a first step to account for the broader B1 variation, we analyzed the distribution of reference voltages in the brain of nine subjects. Based on these results, we repeated a whole-brain CEST experiment with seven different reference voltages to optimize the correction for B1 inhomogeneities in the CEST contrast maps. Additionally, we extended the saturation-offset list to compensate for the higher variation of the static magnetic field for whole-brain experiments compared to examinations with smaller FOVs.

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