Abstract #4022

Thermal measurement in fatty tissues with Z-Spectrum Imaging

Alessandro M Scotti^1,2, Li Li³, Fred Damen¹, Weiguo Li^2,4, Victoria Gil⁵, Wenzhen Zhu³, Chong Wee Liew⁵, and Kejia Cai^1,2

¹Radiology, University of Illinois at Chicago, Chicago, IL, United States, ²Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, ³Radiology, Tongji Medical College, Wuhan, China, ⁴Research Resources Center, University of Illinois at Chicago, Chicago, IL, United States, ⁵Biophysics and Biophysiology, University of Illinois at Chicago, Chicago, IL, United States

Z-spectrum imaging (ZSI) has been recently introduced as a method to quantify fat-water fraction based on the direct saturation of both water and fat. Here we demonstrate that ZSI can also assess temperature in fatty tissues, by measuring the relative fat-water chemical shift (FWCS) change due to the shift of water resonance at increased temperature. The protocol was tested on a whipped cream phantom and showed FWCS changing linearly with temperature. The protocol was also tested on healthy mice and subjects, paving the way for the study of fat metabolism, in particular of brown adipose tissue.

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