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Abstract #4023

A quantitative tool for the speciation of mineralized iron in the brain

Lucia Bossoni1, Laurens Boers2, Andrew G. Webb1, and Louise van der Weerd1,3

1C. J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 2Leiden University, Leiden, Netherlands, 3Human Genetics, Leiden University Medical Center, Leiden, Netherlands

We implemented and optimized an Off-Resonance Saturation (ORS) pulse sequence on a 7T- preclinical scanner, with the aim of quantifying iron present in brain phantoms doped with ferritin-bound and magnetite-bound iron. These mineralized iron forms are known to be involved in ageing, and also in toxic cellular pathways in neurodegenerative diseases. We show that the ORS method offers the possibility to quantify, and possibly differentiate, iron ions in brains affected by neurodegenerative diseases which are characterized by disturbed iron homeostasis. Additionally, our results are discussed in the light of susceptibility values of the same minerals.

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