Abstract #4024

CEST MRI with dual-echo readout for the functional assessment of transplanted kidney in vivo: a preliminary study

Julia Stabinska¹, Alexandra Ljimani¹, Eric Bechler¹, Christian Tell², Helge Jörn Zöllner^1,3, Hans-Jörg Wittsack¹, and Anja Müller-Lutz¹

¹Department of Diagnostic and Interventional Radiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, ²Department of Nephrology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, ³Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

In this study we present the first application of dual-echo CEST MRI technique in renal transplant recipients. Our goal was to optimize the CEST-MRI acquisition and analysis for kidney graft imaging at 3T, which remains technically challenging and volatile due to large B₀ inhomogeneity and presence of fat. Strong lipid signals upfield from the water resonance may lead to erroneous CEST contrast. In this preliminary work we demonstrate that the combination of dual-echo CEST with Dixon provides effective fat signal removal, allowing for more accurate quantification of the CEST effects in the transplanted kidney.

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