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Abstract #4024

CEST MRI with dual-echo readout for the functional assessment of transplanted kidney in vivo: a preliminary study

Julia Stabinska1, Alexandra Ljimani1, Eric Bechler1, Christian Tell2, Helge Jörn Zöllner1,3, Hans-Jörg Wittsack1, and Anja Müller-Lutz1

1Department of Diagnostic and Interventional Radiology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, 2Department of Nephrology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany, 3Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

In this study we present the first application of dual-echo CEST MRI technique in renal transplant recipients. Our goal was to optimize the CEST-MRI acquisition and analysis for kidney graft imaging at 3T, which remains technically challenging and volatile due to large B0 inhomogeneity and presence of fat. Strong lipid signals upfield from the water resonance may lead to erroneous CEST contrast. In this preliminary work we demonstrate that the combination of dual-echo CEST with Dixon provides effective fat signal removal, allowing for more accurate quantification of the CEST effects in the transplanted kidney.

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