Abstract #4060

Multislice and Multidimensional Blood Flow Mapping in Fetal Congenital Heart Disease Using Highly Undersampled Phase-Contrast MRI

Datta Singh Goolaub^1,2, Eric Schrauben², Davide Marini³, Christopher Roy⁴, Mike Seed^3,5, and Christopher K. Macgowan^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, ³Cardiology, Hospital for Sick Children, Toronto, ON, Canada, ⁴Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, ⁵Paediatrics, University of Toronto, Toronto, ON, Canada

In this study, multislice and multidimensional fetal blood flow mapping was performed using highly undersampled radial phase contrast MRI. The goal of this work was to visualize intracardiac flow in human fetuses with congenital heart disease, where complex flow patterns are difficult to capture with conventional, 2D phase contrast techniques. Reconstructions were performed using compressed sensing, with retrospective motion correction and image-based cardiac gating. The developed technique allowed whole fetal heart coverage in reasonable time and provides insight into multi-directional intracardiac flows. We present results from 5 human fetuses with congenital heart disease and demonstrate the first multi-directional intracardiac flows obtained by MRI.

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