Abstract #4068

Assessment of placental microcirculation by joint analysis of flow compensated and non-flow compensated intravoxel incoherent motion data

Esra Abaci Turk¹, Borjan Gagoski¹, Jeffrey N. Stout¹, S. Mazdak Abulnaga^2,3, Natalie Copeland¹, Drucilla J. Roberts⁴, Polina Golland^2,3, Lawrence L. Wald^5,6,7, Elfar Adalsteinsson^2,7,8, William H. Barth Jr⁹, P. Ellen Grant¹, and Yogesh Rathi¹⁰

¹Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ²Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ³Computer Science and Artificial Intelligence Laboratory (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Department of Pathology, Massachusetts General Hospital, Boston, MA, United States, ⁵Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ⁶Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁷Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁸Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁹Maternal-Fetal Medicine, Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, United States, ¹⁰Psychiatry Neuroimaging Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States

Using diffusion weighted imaging and the intravoxel incoherent motion model (IVIM) of blood flow in capillaries, we can measure placental properties relating to maternal and fetal blood flow and perfusion. In this study, we focused on improving the accuracy and precision of the estimated parameters in IVIM imaging by using joint analysis of flow compensated and non-flow compensated diffusion data. With flow compensation, we observed strong re-phasing, approximately cancelling the blood flow effect and allowing more accurate and consistent estimation of diffusion and perfusion measures.

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