Abstract #4069

Fetal Brain-Heart-Placental Interactions with Acute Hypoxia Challenge in Genetic Mouse Models of Hypoplastic Left Heart Syndrome with in utero 4D Dynamic MRI

Anthony G Christodoulou¹, George C Gabriel², Cecilia W Lo², and Yijen L Wu^2,3

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Developmental Biology, University of Pittsburgh, Pittsburgh, PA, United States, ³Rangos Research Center Animal Imaging Core, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, United States

The objective of this study is to develop 4D time-resolved high-resolution in utero MRI for simultaneous interrogation of placenta, heart and brain development and function in genetic mouse models of hypoplastic left heart syndrome. The structural and functional imaging of the fetal heart, brain, and placenta can be correlated with genotype. In addition, temporal and spatial characteristics of BOLD responses to acute hypoxia challenge can be derived.

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