Abstract #4072

T1 and T2 mapping of the placenta and fetal brain with magnetic resonance fingerprinting (MRF) during maternal hyperoxia

Jeffrey N Stout¹, Congyu Liao², Esra Abaci Turk¹, Borjan Gagoski¹, P. Ellen Grant¹, Lawrence L. Wald², and Elfar Adalsteinsson^3,4

¹Fetal-Neonatal Neuroimaging Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ³Harvard-MIT Health Sciences and Technology, IMES, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States

Quantitative MRI may improve diagnosis and monitoring of placental disease by characterizing baseline oxygen content and dynamic oxygen transport during hyperoxia. MRF permits fast quantitative imaging of the adult brain and heart, but use during pregnancy targeting the placenta and fetal brain presents challenges due to motion and large B₁⁺ variation. We tested the accuracy of MRF in phantoms and then scanned pregnant mothers, estimating T₁ and T₂ of the placenta and fetal brain. MRF-based T₁ and T₂ mapping is a promising technique to determine placental oxygenation at baseline and oxygenation changes in the placenta and fetal brain after hyperoxia.

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