Abstract #4073

Reliable assessment of apparent diffusion coefficient in normal and ventriculomegaly fetal brains

Maria Giovanna Di Trani^1,2, Lucia Manganaro³, Amanda Antonelli³, Michele Guerreri², Riccardo De Feo¹, Mattia Borrelli⁴, Giacomo Pratesi⁴, Carlo Catalano³, and Silvia Capuani⁵

¹Centro Fermi - Museo storico della Fisica e centro studi e ricerche Enrico Fermi, Rome, Italy, ²SAIMLAL, Sapienza University of Rome, Rome, Italy, ³Radiological Sciences, Sapienza University of Rome, Rome, Italy, ⁴Physics, Sapienza University of Rome, Rome, Italy, ⁵Physics, CNR-Institute for Complex Systems, Rome, Italy

Ventriculomegaly (VM) is one of the most common disease in fetuses; however, DWI studies during gestation are scarce. In this work, DWI was performed in normal and VM fetal brains at different gestational ages (GA) and ADC was calculated. Denoising and artifacts corrections were used to improve signal-to-noise ratio and the reliability of measures. We found significant variations in ADC as GA increases, reflecting microstructural changes due to brain maturation. Moreover, ventricles dilatation measured on DWIs provided an accurate classification of VM. DWI with artifacts corrections could be a powerful tool to evaluate brain abnormalities and accurately diagnose VM.

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