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Abstract #4084

A Comprehensive Pipeline for non-contrast enhanced Pulmonary Vascular 1H MRI

Alexander M Matheson1,2, Dante PI Capaldi3, Fumin Guo4, David G McCormack5, and Grace Parraga1,2,5

1Robarts Research Institute, London, ON, Canada, 2Medical Biophysics, Western University, London, ON, Canada, 3Radiation Oncology, Stanford University, Stanford, CA, United States, 4Medical Biophysics, University of Toronto, Toronto, ON, Canada, 5Medicine, Division of Respirology, Western University, London, ON, Canada

Structure-function relationships are central to our understanding of pulmonary disease and play an important role in evaluating novel therapies. Many chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), have vascular abnormalities that are not accounted for in current image analysis platforms. Recent MRI developments provide complementary pulmonary vascular structural and functional information and include ultra-short echo time and Fourier-decomposition MRI. To facilitate clinical translation, we developed a comprehensive structure-function pipeline to visualize and measure pulmonary vascular vessel trees and perfusion for patients with severe asthma, a demanding clinical target.

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