Abstract #4084

A Comprehensive Pipeline for non-contrast enhanced Pulmonary Vascular 1H MRI

Alexander M Matheson^1,2, Dante PI Capaldi³, Fumin Guo⁴, David G McCormack⁵, and Grace Parraga^1,2,5

¹Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada, ³Radiation Oncology, Stanford University, Stanford, CA, United States, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Medicine, Division of Respirology, Western University, London, ON, Canada

Structure-function relationships are central to our understanding of pulmonary disease and play an important role in evaluating novel therapies. Many chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), have vascular abnormalities that are not accounted for in current image analysis platforms. Recent MRI developments provide complementary pulmonary vascular structural and functional information and include ultra-short echo time and Fourier-decomposition MRI. To facilitate clinical translation, we developed a comprehensive structure-function pipeline to visualize and measure pulmonary vascular vessel trees and perfusion for patients with severe asthma, a demanding clinical target.

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