Abstract #4085

Flow-Compensated Ventilation and Perfusion Fourier-decomposition Pulmonary MRI

Alexander M Matheson^1,2, Dante PI Capaldi³, Fumin Guo⁴, and Grace Parraga^1,2,5

¹Robarts Research Institute, London, ON, Canada, ²Medical Biophysics, Western University, London, ON, Canada, ³Radiation Oncology, Stanford University, Stanford, CA, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Medicine, Division of Respirology, Western University, London, ON, Canada

Fourier-decomposition pulmonary MRI ventilation and perfusion maps are subject to substantial flow artifacts stemming from cardiac frequencies which makes lung perfusion measurements complex and in some regions of interest, impossible to acquire. We eliminated flow artifacts by shimming only on cardiac regions, instead of the entire field-of-view. Flow compensation improved vessel resolution and segmentation around the heart but also increased the incidence of off-resonance banding artifacts around the diaphragm. MRI ventilation defect percent was greater in flow-compensated versus uncompensated images as well as hyperpolarized gas MRI, demonstrating that ventilation images are highly sensitive to changes in field inhomogeneities.

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