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Abstract #4091

Pseudo-diffusion effects in lung MRI

Lukas Buschle1, Christian Ziener1, Thomas Kampf2, Volker Sturm3, Ke Zhang1, Sabine Heiland3, Martin Bendszus3, Heinz-Peter Schlemmer1, and Felix Kurz3

1Radiology, German Cancer Research Center, Heidelberg, Germany, 2Neuroradiology, University Hospital Wuerzburg, Wuerzburg, Germany, 3Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany

Magnetic resonance imaging of lung tissue is strongly influenced by susceptibility effects between spin-bearing water molecules and air-filled alveoli. The measured lineshape, however, also depends on the blood-flow around alveoli that can be approximated as pseudo-diffusion. Both effects are quantitatively described by the Bloch-Torrey-equation, which was so far only solved for dephasing on the alveolar surface. In this work, we extend this model to the whole range of physiological relevant air volume fractions. The results agree very well with in vivo measurements in human lung tissue.

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