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Abstract #4109

Parenchymal Enhancement in Peritumoral Breast Tissue During DCE-MRI Reflects Response to Neoadjuvant Therapy

John Virostko1, Erin M Higgins1, Chengyue Wu1, Anna G Sorace1, and Thomas E Yankeelov1

1The University of Texas at Austin, Austin, TX, United States

DCE-MRI induced enhancement of fibroglandular parenchyma surrounding breast tumors reflects response to neoadjuvant therapy. Longitudinal MRI performed over the course of NAT demonstrates progressive declines in fibroglandular parenchymal enhancement, with more pronounced declines in patients achieving favorable response to therapy. The degree of parenchymal enhancement is affected by patient age and increases with both tumor enhancement and proximity to the tumor.

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