Abstract #4112

Diffusion-weighted imaging with apparent diffusion coefficient (ADC) mapping in non-mass enhancing breast tumors: influence of region-of-interest placement in diagnostic accuracy and intra-/inter-reader agreement

Daly Avendano^1,2, Maria Adele Marino^1,3, Doris Leithner⁴, Blanca Bernard-Davila⁴, Maxine Jochelson⁴, Elizabeth Morris⁴, Pascal Baltzer⁵, Thomas Helbich⁵, and Katja Pinker^4,5

¹Breast imaging service, Memorial Sloan Kettering Cancer Center, New York, NY, NY, United States, ²Breast imaging, Department of Breast Imaging, Breast Cancer Center TecSalud, ITESM Monterrey, Nuevo Leon, Mexico, Monterrey, Mexico, ³Department of Biomedical Sciences and Morphologic and Functional Imaging, University of Messina, Messina, Italy, Department of Biomedical Sciences and Morphologic and Functional Imaging, University of Messina, Messina, Italy, Messina, Italy, ⁴Breast imaging service, Memorial Sloan Kettering Cancer Center, New york, NY, United States, ⁵Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University Vienna, Vienna, Austria, Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University Vienna, Vienna, Austria, Viena, Austria

Non-mass enhancing (NME) breast tumors are a diagnostic challenge and limited data exists for characterization with DWI with ADC mapping. We aim to investigate the influence of ROI placement and different ADC metrics on diagnostic accuracy of DWI and to assess intra and inter-reader agreement of ADC measurements with DWI in NME breast lesions. Two readers independently assessed DWI using three different ROI´s approaches for ADC measurements. Data indicate that diagnostic accuracy of DWI with ADC mapping is limited in lesions presenting as NME on DCE-MRI with only moderate inter-reader agreement

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