Abstract #4136

Comparison of hyperpolarised 3He and 129Xe ventilation MRI to assess lung disease in cystic fibrosis

Laurie J Smith^1,2, Guilhem J Collier¹, Helen Marshall¹, Paul J.C Hughes¹, Alberto Biancardi¹, Graham Norquay¹, Jody Bray¹, Oliver Rodgers¹, Martin Wildman³, Noreen West², Alex Horsley⁴, and Jim Wild¹

¹POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom, ²Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom, ³Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, ⁴Respiratory research group, Division of infection, immunity and respiratory medicine, University of Manchester, Manchester, United Kingdom

Ventilation MRI using hyperpolarised gases is highly sensitive to early cystic fibrosis lung disease. With the recent move towards ¹²⁹Xe from ³He, we aimed to assess both gases in parallel in patients with CF, at baseline and follow-up, to determine whether any inherent bias was present when assessing lung disease. We found that there was no inherent bias for VDP between the two gases present although at an individual level differences were evident. Despite this, when followed up at a later date both gases similarly reflected changes in ventilation, suggesting both are capable of reflecting CF lung disease severity.

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