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Abstract #4137

129Xe ventilation and 1H anatomical MRI to detect functional and structural abnormalities in sub-clinical cystic fibrosis lung disease

Laurie J Smith1,2, David Hughes2, Ho-Fung Chan1, Kevin M Johnson3, Jody Bray1, Oliver Rodgers1, Guilhem J Collier1, Graham Norquay1, Alberto Biancardi1, Paul J.C Hughes1, Sailesh Kotecha4, Martin Wildman5, Noreen West2, Alex Horsley6, Pierluigi Ciet7, Piotr Wielopolski7, Harm Tiddens8, Helen Marshall1, and Jim Wild1

1POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 2Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom, 3Departments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, United States, 4Cardiff University, Cardiff, United Kingdom, 5Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, 6Respiratory research group, Division of infection, immunity and respiratory medicine, University of Manchester, Manchester, United Kingdom, 7Radiology and Nuclear Medicine department, Erasmus Medical Centre, Rotterdam, Netherlands, 8Paediatric Pulmonology Department, Sophia Children's hospital, Erasmus Medical Centre, Rotterdam, Netherlands

Lung MRI in cystic fibrosis (CF) has the potential to measure both structure and function during the same session. Here we assessed 14 patients with CF and normal spirometry for lung abnormalities using 129Xe ventilation and 1H 3D SPGR and UTE anatomical MRI. 129Xe ventilation defects were evident in all subjects assessed, whilst gas trapping was evident on expiratory 3D SPGR in 71% of patients. Further anatomical abnormalities were evident on UTE in 57% of patients. Ventilation and anatomical abnormalities are therefore present in sub-clinical CF and highlights the potential of MRI in routine CF lung imaging.

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