Lung MRI in cystic fibrosis (CF) has the potential to measure both structure and function during the same session. Here we assessed 14 patients with CF and normal spirometry for lung abnormalities using 129Xe ventilation and 1H 3D SPGR and UTE anatomical MRI. 129Xe ventilation defects were evident in all subjects assessed, whilst gas trapping was evident on expiratory 3D SPGR in 71% of patients. Further anatomical abnormalities were evident on UTE in 57% of patients. Ventilation and anatomical abnormalities are therefore present in sub-clinical CF and highlights the potential of MRI in routine CF lung imaging.