Abstract #4137

129Xe ventilation and 1H anatomical MRI to detect functional and structural abnormalities in sub-clinical cystic fibrosis lung disease

Laurie J Smith^1,2, David Hughes², Ho-Fung Chan¹, Kevin M Johnson³, Jody Bray¹, Oliver Rodgers¹, Guilhem J Collier¹, Graham Norquay¹, Alberto Biancardi¹, Paul J.C Hughes¹, Sailesh Kotecha⁴, Martin Wildman⁵, Noreen West², Alex Horsley⁶, Pierluigi Ciet⁷, Piotr Wielopolski⁷, Harm Tiddens⁸, Helen Marshall¹, and Jim Wild¹

¹POLARIS, Academic Radiology, University of Sheffield, Sheffield, United Kingdom, ²Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom, ³Departments of Radiology and Medical Physics, University of Wisconsin, Madison, WI, United States, ⁴Cardiff University, Cardiff, United Kingdom, ⁵Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, ⁶Respiratory research group, Division of infection, immunity and respiratory medicine, University of Manchester, Manchester, United Kingdom, ⁷Radiology and Nuclear Medicine department, Erasmus Medical Centre, Rotterdam, Netherlands, ⁸Paediatric Pulmonology Department, Sophia Children's hospital, Erasmus Medical Centre, Rotterdam, Netherlands

Lung MRI in cystic fibrosis (CF) has the potential to measure both structure and function during the same session. Here we assessed 14 patients with CF and normal spirometry for lung abnormalities using ¹²⁹Xe ventilation and ¹H 3D SPGR and UTE anatomical MRI. ¹²⁹Xe ventilation defects were evident in all subjects assessed, whilst gas trapping was evident on expiratory 3D SPGR in 71% of patients. Further anatomical abnormalities were evident on UTE in 57% of patients. Ventilation and anatomical abnormalities are therefore present in sub-clinical CF and highlights the potential of MRI in routine CF lung imaging.

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