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Abstract #4141

Mapping and Correcting Hyperpolarized Magnetization Decay Using Radial Keyhole Imaging

Peter J Niedbalski1, Matthew M. Willmering1, Scott H. Robertson2, Matthew S. Freeman1, Wolfgang Loew3, Randy O. Giaquinto3, Christopher Ireland3,4, Ronald G. Pratt3, Charles L. Dumoulin3,4,5, Jason C. Woods1,3,5, and Zackary I. Cleveland1,3,4,5

1Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Clinical Imaging Physics Group, Department of Radiology, Duke University Medical Center, Durham, NC, United States, 3Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 4Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH, United States, 5Department of Pediatrics, University of Cincinnati Medical Center, Cincinnati, OH, United States

Hyperpolarized (HP) media enable biomedical imaging applications otherwise unachievable using standard MRI contrast agents. However, quantitative analysis of HP images is complicated by spatially varying signal decay due to T1 relaxation and RF excitation. By imaging with center-out trajectories, HP signal intensity is collected with every acquisition, thereby encoding signal decay alongside k-space data. Using keyhole reconstruction, multiple temporally resolved images were reconstructed to generate voxel-by-voxel maps of hyperpolarized signal decay following a simple analytical model. Here these maps are applied to correct spatially varying magnetization decay in HP 129Xe, improving the quantitative accuracy of ventilation images.

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