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Abstract #4142

Feasibility of Single Breath-hold Isotropic Voxel 129Xe MRI in Patients

Andrea L Barker1,2, Andrew L Westcott1,2, Rachel L Eddy1,2, David G McCormack3, Grace Parraga1,2,3, and Alexei L Ouriadov1

1Robarts Research Institute, London, ON, Canada, 2Medical Biophysics, Western University, London, ON, Canada, 3Division of Respirology, Department of Medicine, Western University, London, ON, Canada

Hyperpolarized 129Xe gas MRI has been established as an effective tool to investigate lung function in a number of pulmonary diseases. Improved 129Xe polarization techniques provide the opportunity to use a high-resolution 3D static ventilation image acquisition sequence (FGRE) in a 16-second breath-hold. Isotropic-voxel images were acquired in one healthy-volunteer and two patients with asthma; images were compared to coronal images acquired in two other patients with asthma. Isotropic images had sufficient SNR to analyze VDP. This proof-of-concept investigation establishes the feasibility of using an isotropic-voxel acquisition sequence in single breath-hold MRI of the lungs.

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