The solubility properties of hyperpolarized 129Xe have made it attractive in many translational pulmonary imaging studies; the large chemical-shift range can be exploited to obtain semi-quantitative ventilation, barrier-uptake, and RBC-transfer images. To date, the technique has demonstrated significant changes in gas exchange in adult lung disease, but has yet to be explored in children, where pulmonary function testing can be more challenging (or impossible). This pediatric gap caused us to pursue 129Xe gas-exchange MRI at the now-common field of 3T; here, we present the first demonstration of dissolved-phase xenon imaging in pediatrics (with cystic fibrosis and post-bone marrow transplant).
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