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Abstract #4148

129Xe Gas-Exchange MRI in Pediatrics with Lung Disease

Matthew M. Willmering1, Ziyi Wang2, Hui Wang1,3,4, Laura L. Walkup1, Bastiaan Driehuys2,5, Zackary I. Cleveland1,4,6, and Jason C. Woods1,4,6

1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Duke University, Durham, NC, United States, 3Philips, Cincinnati, OH, United States, 4University of Cincinnati, Cincinnati, OH, United States, 5Duke University Medical Center, Durham, NC, United States, 6University of Cincinnati Medical Center, Cincinnati, OH, United States

The solubility properties of hyperpolarized 129Xe have made it attractive in many translational pulmonary imaging studies; the large chemical-shift range can be exploited to obtain semi-quantitative ventilation, barrier-uptake, and RBC-transfer images. To date, the technique has demonstrated significant changes in gas exchange in adult lung disease, but has yet to be explored in children, where pulmonary function testing can be more challenging (or impossible). This pediatric gap caused us to pursue 129Xe gas-exchange MRI at the now-common field of 3T; here, we present the first demonstration of dissolved-phase xenon imaging in pediatrics (with cystic fibrosis and post-bone marrow transplant).

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