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Abstract #4149

Xenon-129 MRI of the lung in cystic fibrosis – preliminary results from a clinical trial

Vicki Huang1, Dana Albon2, Lucy Gettle2, Kun Qing1, Nicholas Tustison1, Yun Shim2, John Mugler1, James Patrie3, and Jaime Mata1

1Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, United States, 2Medicine, University of Virginia, Charlottesville, VA, United States, 3Public Health, University of Virginia, Charlottesville, VA, United States

Results demonstrate sensitivity to early physiologic changes in subjects with cystic fibrosis (CF) using 3D single breath-hold chemical shift imaging (3D-SBCSI). 3D-SBCSI is a technique that uses MRI and hyperpolarized Xenon-129, an inert, non-radioactive gas, to assess lung physiology by detecting Xe-129 in three compartments in the lungs: airspaces, tissue parenchyma and plasma, and red-blood-cells. Results of 3D-SBCSI were compared to pulmonary function test results, Xe-129 ventilation images, blood panels and showed early physiologic trends in mild subjects that progressed on severe CF subjects. 3D-SBCSI could be used to monitor treatment responses and disease progression before symptoms become clinically apparent.

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