Results demonstrate sensitivity to early physiologic changes in subjects with cystic fibrosis (CF) using 3D single breath-hold chemical shift imaging (3D-SBCSI). 3D-SBCSI is a technique that uses MRI and hyperpolarized Xenon-129, an inert, non-radioactive gas, to assess lung physiology by detecting Xe-129 in three compartments in the lungs: airspaces, tissue parenchyma and plasma, and red-blood-cells. Results of 3D-SBCSI were compared to pulmonary function test results, Xe-129 ventilation images, blood panels and showed early physiologic trends in mild subjects that progressed on severe CF subjects. 3D-SBCSI could be used to monitor treatment responses and disease progression before symptoms become clinically apparent.
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