Abstract #4202

Non-invasive assessment of myocardial cell viability based on 23Na triple-quantum signal

Michaela A U Hoesl¹, Till Wüstemann², Matthias Malzacher¹, Cordula Nies³, Eric Gottwald³, and Lothar R Schad¹

¹Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Department for Molecular Cardiology and Epigenetics, Heidelberg University, Heidelberg, Germany, ³Institute of Functional Interfaces, Karlsruhe Institute of Technology, Karlsruhe, Germany

Sodium MRI was proposed in addition to cardiovascular magnetic resonance methods to detect viable cells. In this work, a spectroscopic sequence with time proportional phase increments was used to measure single- and triple quantum coherences of the spin 3/2 sodium nuclei simultaneously. We investigated the sodium triple-quantum signal of cardiomyocytes in an MR compatible bioreactor to gain further understanding of the TQ signal of cardiomyocytes under stimulation. This setup may be applied in the future to simulate additional diseases as well as potentially monitor the single-quantum and triple-quantum signal changes, e.g. in hypertrophy and after myocardial infarction in-vivo.

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