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Abstract #4203

31P Single Voxel MRS in the Human Brain at 9.4T: ISIS versus SemiLASER

Johanna Dorst1, Loreen Ruhm1, Nikolai Avdievich1, Wolfgang Bogner2, and Anke Henning1

1High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 2High-Field MR Center, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria

In vivo phosphorus MR spectroscopy has been established to be a powerful tool for studies of energy metabolism. To provide clinically relevant information about physiologic function, accurate spatial localization as well as sufficient spectral quality are fundamental requirements. Therefore, in this study, first steps to optimize a multi-shot ISIS sequence and a single-shot semiLASER sequence for phosphorus MR spectroscopy in the human brain at 9.4T have been taken. The sequences were compared in terms of localization accuracy and SNR.

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