Abstract #4206

Oxygen-17 MRI Reveals Unchanged Cerebral Metabolic Rate in Aquaporin-4 Knockout Mice

Yifan Zhang¹, Yuchi Liu², Kui A Xu³, Ciro Ramos-Estebanez³, George W Farr⁴, Joseph C LaManna⁴, Walter F Boron⁴, and Xin Yu²

¹Radiology, Case Western Reserve University, Cleveland, OH, United States, ²Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ³Neurology, Case Western Reserve University, Cleveland, OH, United States, ⁴Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States

This study aimed at investigating the role of aquaporin-4 (AQP-4)-facilitated gas transport in regulating cerebral metabolism. Cerebral metabolic rate of oxygen (CMRO₂) was quantified in AQP-4 knockout and wildtype control mice using oxygen-17 (¹⁷O) MRI. Our results showed no change in CMRO₂ in AQP-4 knockout mice, suggesting that AQP4-facilitated gas transport is not a rate-limiting factor in cerebral metabolism in anesthetized mice.

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