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Abstract #4212

Preliminary investigation into the effect of diuretic treatment on in vivo skin sodium using ultra-short echo time 23Na MRI at 3T with biopsy validation

Frank Riemer1, Joshua D Kaggie1, Mary A McLean1,2, Viknesh Selvarajah3, Kathleen Connolly3, Ilse Patterson4, Bruno do Carmo4, Rolf F Schulte5, Ian B Wilkinson3, Martin J Graves1, and Ferdia A Gallagher1

1Department of Radiology, University of Cambridge, Cambridge, United Kingdom, 2Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, 3Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, United Kingdom, 4Department of Radiology, Addenbrooke's Hospital NHS Foundation Trust, Cambridge, United Kingdom, 5GE Healthcare, Munich, Germany

In this ongoing study, we investigate the changes in skin sodium concentration between controls and a group receiving a diuretic for seven days and present results from an interim analysis. Ultra-short echo time 23Na-MRI is performed at baseline and after seven days, at the end treatment. Results are correlated with measurements of sodium from biopsy samples.

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