Abstract #4212

Preliminary investigation into the effect of diuretic treatment on in vivo skin sodium using ultra-short echo time 23Na MRI at 3T with biopsy validation

Frank Riemer¹, Joshua D Kaggie¹, Mary A McLean^1,2, Viknesh Selvarajah³, Kathleen Connolly³, Ilse Patterson⁴, Bruno do Carmo⁴, Rolf F Schulte⁵, Ian B Wilkinson³, Martin J Graves¹, and Ferdia A Gallagher¹

¹Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ²Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom, ³Division of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, United Kingdom, ⁴Department of Radiology, Addenbrooke's Hospital NHS Foundation Trust, Cambridge, United Kingdom, ⁵GE Healthcare, Munich, Germany

In this ongoing study, we investigate the changes in skin sodium concentration between controls and a group receiving a diuretic for seven days and present results from an interim analysis. Ultra-short echo time ²³Na-MRI is performed at baseline and after seven days, at the end treatment. Results are correlated with measurements of sodium from biopsy samples.

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