Meeting Banner
Abstract #4215

Metabolic Brain Tumor Analysis: Correlation between ADC/ CBV and quantitative CMRO2 employing dynamic 17O MRI

Sebastian C. Niesporek1, Nina Weinfurtner2, Armin M. Nagel1,3, Mark E. Ladd1, Heinz-Peter Schlemmer2, and Daniel Paech2

1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany

Dynamic 17O-MRI enables a direct measurement of the cerebral metabolic rate of oxygen (CMRO2). Decreased CMRO2 in tumor tissue indicates a change in the metabolic pathway and therefore metabolic imaging can be used as a diagnostic parameter. Data of three high grade tumor patients where investigated with regard to cerebral blood volume (CBV) hyper-intense and apparent diffusion coefficient (ADC) hypo-intense areas to exclude bias of perfusion and ADC. No significant change in CBV+ and ADC- volumes demonstrates the independence of tissue perfusion and cellular density of utilized method and underline the capability of fully quantitative metabolic imaging.

This abstract and the presentation materials are available to members only; a login is required.

Join Here