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Abstract #4216

Multiparametric statistical quantification of the heterogeneity of free Na+ concentration by 19F NMR spectroscopy

Norbert W Lutz1 and Monique Bernard1

1CRMBM, Aix Marseille University, Marseille, France

Sodium(I) (Na+) plays a key role in basic cell function. Noninvasive methods for measuring intracellular Na+ concentrations ([Na+]i) in biological tissue have been developed on the basis of 19F NMR spectroscopy. By contrast, 23Na MRI at most provides approximate (relative) contributions of intracellular Na+ to total 23Na by relying on a number of theoretical assumptions, as it does not detect Na+i selectively. Since [Na+]i values are often not uniform throughout a given tissue volume (or voxel), we have designed an approach for quantifying total [Na+]i heterogeneity by exploiting the lineshape of the 19F resonance of an appropriate [Na+]i reporter molecule.

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