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Abstract #4223

Protocol Optimization for Functional 17O-MRI of Donor Kidneys at 3T

Yanis Taege1, Johannes Fischer1, Ali Çağlar Özen1,2, Hao Song1, Christian Schuch3, Rianne Schutter4, Cyril Moers4, Ronald JH Borra5, and Michael Bock1

1Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, 2German Cancer Consortium Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, Germany, 3NUKEM Isotopes GmbH, Alzenau, Germany, 4Department of Surgery – Organ Donation and Transplantation, University Medical Center Groningen, Groningen, Netherlands, 5Medical Imaging Center, University Medical Center Groningen, Groningen, Netherlands

Direct 17O-MRI is able to measure the dynamics of renal metabolism in a porcine kidney in an organ transplantation setup at 3T. To obtain stable SNRs above 20 over time while maintaining a spatial resolution below 8 mm, we investigated the influence of nominal spatial resolution, bandwidth and acquisition time window of a UTE-sequence with a golden-angle acquisition pattern on SNR. Signal increase of up to 25% per liter of 17O-gas was observed in a pilot experiment.

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