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Abstract #4222

Limitation of glucose consumption in rat head detected by labeled glucose-17O

Victor D. Schepkin1, Shannon Helsper1, and Cathy Levenson2

1Florida State University/NHMFL, Tallahassee, FL, United States, 2MSR, Florida State University/NHMFL, Tallahassee, FL, United States

In animal experiments using 17O labeled glucose, questions arose regarding the relatively stable rate of glucose metabolism, compared with a simultaneous variation in glucose concentration after bolus injection. Bolus Glucose-6-17O administration with doses 3-15 μmol/g for normal rats revealed the same glucose consumption with CMRglc = 0.43 ± 0.06 μmol/g tissue/min. After bolus injection, the rate of glucose metabolism was consistent in each dose regardless of the large variation in glucose concentration. The results correlate with the observations of others, indicating that glucose-6-phosphate (G-6-P) does not accumulate in hyperglycemia and can limit glucose consumption.

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