Meeting Banner
Abstract #4221

Non-invasive intracranial detection of the small molecule inhibitor BAY 1436032 in an orthotopic glioma model using 19F MR spectroscopy

Katharina J Wenger1, Michael Burger2, Christian Richter3, Joachim Steinbach2, Harald Schwalbe3, Stefan Kaulfuss4, Elke Hattingen1, Bähr Oliver2, and Ulrich Pilatus1

1Neuroradiology, University Hospital Frankfurt, Frankfurt, Germany, 2Neurooncology, University Hospital Frankfurt, Frankfurt, Germany, 3Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, Frankfurt, Germany, 4Research&Development Pharmaceuticals, Bayer AG Berlin, Berlin, Germany

BAY 1436032 is a small-molecule inhibitor of the R132X-mutant form of IDH1 with a trifluoromethoxy-group that is currently clinically investigated in IDH1-mutant solid tumors. Non-invasive monitoring of intracranial drug delivery of BAY 1436032 in an animal model using 19F MRS is technically challenging but feasible.

This abstract and the presentation materials are available to members only; a login is required.

Join Here