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Abstract #4235

T2 Measurement and quantification of cerebral white and gray matter aspartate concentrations in vivo

Petr Menshchikov1,2, Andrei Manzhurtsev2,3, Maxim Ublinskii 2, Tolib Akhadov2, and Natalia Semenova1,2,3

1Semenov Institute of Chemical Physics of RAS, Moscow, Russian Federation, 2Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, 3Emanuele Institute of Biochemical Physics of RAS, Moscow, Russian Federation

In this study for the first time in vivo transverse relaxation rate (T2) of aspartate (Asp) from Asp edited MEGA-PRESS spectra using phanton data were quantified as 161±33 ms. Asp concentrations in gray matter (GM)- and white matter (WM)-dominant brain regions were measured as 2.78±0.21 mM vs 1.04±0.16 mM, respectively. Estimation of the absolute Asp concentrations with Asp editing MEGA-PRESS has potential in many research applications, such as studying the processes underlying the reduction of N‐acetyl aspartate. The T2 measurement method which has been successfully applied for edited Asp signals can also be used for other strongly J-coupled signals.

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