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Abstract #4244

Effects of outer volume saturation RF pulses and chemical shift displacement on MRS data

Diana G. Rotaru1, Dimitra Tsivaka2, and David J. Lythgoe1

1Neuroimaging, King's College London, London, United Kingdom, 2Department of Medical Physics, University of Thessaly, Larissa, Greece

We investigated the effect of outer volume saturation (OVS) using very selective saturation pulses (VSS) on metabolite concentrations in PRESS MRS. Our results show that if the PRESS excitation voxel isn’t increased in size, metabolite concentrations are overestimated compared with not using VSS-OVS. These results will be of interest to other researchers planning or conducting multi-centre MRS studies.

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