Abstract #4249

Comparison of 7T MRS Reproducibility Using either Creatine or Water Referencing in Patients with Schizophrenia

Anna Min Wang^1,2, Laura M Rowland^1,3, Andrea Wijtenburg³, and Peter B Barker^1,2

¹Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, United States

This study investigated the reproducibility of 7T MRS of gray and white matter in ten patients with schizophrenia (SZ), using either water or total creatine (tCr) as internal references. All ‘high concentration’ metabolites such as NAA, glutamate, choline and others, and some low concentration metabolites, such as glutamine and NAAG were reliably determined. Referencing to either water or tCr gave similar reproducibility.

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