Abstract #4250

Ultra-high field MRS and high spatiotemporal resting fMRI of the default mode network: A reproducibility study

Bradford A Moffat¹, Ofer Gonen¹, Rebecca Glarin¹, Patrick Kwan², Patricia Desmond¹, Elaine Lui¹, and Terry O'Brien^2,3

¹Medicine and Radiology, University of Melbourne, Parkville, Australia, ²Monash University, Monash, Australia, ³Alfred Hospital, Richmond, Australia

This study investigated the reproducibility of measuring brain glutamatergic nuerotransmitters and glutathione using MRS, and their correlation with high spatiotemporal resolution resting state fMRI and subject age at 7T. Repeat MRS measurements across two time points showed excellent reproducibility (ICC > 0.75) for all metabolites. Both the ratio of Glutamate/Gaba and functional connectivity correlated independently with subject age. Ultra-high field MR is ideal for studying the association between brain biochemistry and function in neurological diseases.

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