Abstract #4253

Regional Differences in Cerebral Phenylalanine Measured with Single Voxel Spectroscopy using PRESS localization and LCModel Quantification

Eduardo Coello¹, Huijun Liao¹, Cassandra Papaleo², Molly F. Charney¹, Tyler C. Starr¹, Sai K. Merugumala¹, Susan Waisbren², and Alexander P. Lin¹

¹Radiology, Brigham and Women's Hospital, Boston, MA, United States, ²Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, United States

This work describes a methodology for the quantification of phenylalanine in the brain, using standard single voxel spectroscopy with PRESS localization and LCModel quantification. The signals downfield from the water peak were modeled incorporating metabolite basis functions to the standard LCModel basis set. Phantom calibrations tailored for the acquisition protocol were performed to obtain corrected concentration ratios that showed significant regional differences (p<0.001) and high intrasubject correlation (R=0.73).

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