Abstract #4254

Distribution of Major Brain Metabolite Ratios in Adults: The Observations of Whole Brain Magnetic Resonance Spectroscopic Imaging Study

Xinnan Li¹, Khin Khin Tha^2,3, Kagari Khin Abiko⁴, Sinyeob Ahn⁵, Yuta Urushibata⁶, Kohsuke Kudo², and Hiroki Shirato¹

¹Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan, ²Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, ³Global Station for Quantum Medical Science and Engineering, Hokkaido University, Sapporo, Japan, ⁴Hokkaido University Hospital, Sapporo, Japan, ⁵Siemens Healthineers, San Francisco, CA, United States, ⁶Siemens Healthcare K.K., Tokyo, Japan

We evaluated the normative major metabolite ratios of adults by using whole-brain magnetic resonance spectroscopic imaging (MRSI). The major metabolite ratios of the brain vary with region, age and gender. The respective reference values are necessary to interpret the alterations in metabolite ratios in disease states. The whole brain MRSI allows quantification of major metabolite ratios of the entire brain in a single acquisition, and can become a useful tool in clinical studies.

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