Abstract #4258

TAT-functionalized perfluorocarbon nanoemulsion for 19F imaging of CAR T cells in vivo.

Dina Vinoo Hingorani¹, Fanny Chapelin², Emma Stares¹, Stephen R Adams³, Hideho Okada⁴, and Eric T Ahrens¹

¹Radiology, University of California San Diego, La Jolla, CA, United States, ²Bioengineering, University of California San Diego, La Jolla, CA, United States, ³Pharmacology, University of California San Diego, La Jolla, CA, United States, ⁴Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

To improve the utility of 19F MRI to detect lymphocytes in vivo, we looked into strategies to increase cell loading via the use of cell penetrating peptides as a component of perfluorocarbon (PFC) nanoemulsion formulation. We show an 8-fold increase in cell uptake without viability impairment. This TAT-PFC formulation can be used to provide insight into the modes of action of engineered T cell immunotherapy against cancer.

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